Skin cancer occurs when errors (mutations) occur in the DNA of skin cells. The mutations cause the cells to grow out of control and form a mass of cancer cells.
Cells involved in skin cancer
Skin cancer begins in your skin's top layer — the epidermis. The epidermis is a thin layer that provides a protective cover of skin cells that your body continually sheds. The epidermis contains three main types of cells:
- Squamous cells lie just below the outer surface and function as the skin's inner lining.
- Basal cells, which produce new skin cells, sit beneath the squamous cells.
- Melanocytes — which produce melanin, the pigment that gives skin its normal color — are located in the lower part of your epidermis. Melanocytes produce more melanin when you're in the sun to help protect the deeper layers of your skin.
Where your skin cancer begins determines its type and your treatment options.
Ultraviolet light and other potential causes
Much of the damage to DNA in skin cells results from ultraviolet (UV) radiation found in sunlight and in the lights used in tanning beds. But sun exposure doesn't explain skin cancers that develop on skin not ordinarily exposed to sunlight. This indicates that other factors may contribute to your risk of skin cancer, such as being exposed to toxic substances or having a condition that weakens your immune system.
Age
The older you are, the more likely you are to develop non melanoma skin cancer. But skin cancers can develop in younger people too.
Previous skin cancer
A diagnosis of melanoma means that you have a 3 times higher than average risk of getting a non melanoma skin cancer.
Being diagnosed with a non melanoma skin cancer means that you:
- have about a 10 times higher risk of a second non melanoma skin cancer
- might also be at an increased risk of developing a second primary cancer (other than skin cancer), it's not clear why
Family history of skin cancer
Most non melanoma skin cancers don't run in families. But research has found some families seem to have a higher number than normal. You have an increased risk of developing a squamous cell skin cancer (SCC) if one of your parents has had an SCC. People who have a family history of melanoma have an increased risk of basal cell skin cancer (BCC).
Of course, skin type runs in families. So people from fair skinned families will be more at risk. But there might be some other inherited genes that increase the risk of non melanoma skin cancer in some families.
Sun exposure
Most skin cancers are caused by exposure to the sun. This may be long term exposure, or short periods of intense sun exposure and burning. The ultraviolet light in sunlight damages the DNA in the skin cells. This damage can happen years before a cancer develops.